Pain After Eye Injections

Why are eye injections given?

There are many conditions, which threaten loss of vision, that are treated by injecting various medications into the eye. The eye conditions include macular degeneration, diabetic retinopathy, retinal vein occlusion, uveitis, and others.  The injections may be given into the tissues outside the eyeball (subtenon’s injections) or into the eyeball (intravitreal injections).  It is very important to avoid pain as these injections may need to be given repeatedly over time.

Why do I have pain after eye injections?

Although pain during eye injections can usually be minimized with anesthetics given before the injection, sometimes there is pain for hours after the injection.  There are many reasons why this may occur:

1.) The antibiotic (betadine) may irritate the eye for hours after it has been applied to the eye.

2.) The eye may become dried out after the injection due to insufficient blinking.

3.) The eye may be accidentally scratched by rubbing the eye while it is still anesthetized.  

4.) The drug that is injected into the eye may cause an inflammatory reaction.

5.) Rarely, a severe infection called endophthalmitis may occur after injection into the eyeball.  

What can be done to prevent pain after injections?

The key to eliminating pain after eye injections is to identify the underlying cause. This may take some detective work.  Although betadine is given at the time of injection to prevent infection, only a small dose is needed.  If a large amount of betadine is used or if the betadine has not been thoroughly rinsed off the eye, it may cause blurred vision, persistent burning, itching, and/or a scratchy sensation like sand in the eye (called a foreign body sensation).  Therefore, it is important for the eye doctor or technician to completely rinse the betadine off the eye after an eye injection in order to avoid pain later.

Sometimes, the surface of the eye may become dry after an injection because the patient does not blink frequently enough or not completely enough.  This often happens as a result of the anesthetic used in preparation for the injection.  After the injection is over, the anesthetic may continue to work for 15-30 minutes.  During that time, the patient does not have the normal sensation necessary to indicate that it is time to blink.  If the eye does not blink often enough, the surface may dry out and cause blurred vision, pain or foreign body sensation.  Therefore, the patient may need to purposefully blink frequently or simply rest the eye closed for a while after an eye injection in order to prevent drying.  Similarly, if a patient does not close the eye completely with each blink, part of the eye can become dry.  In some cases, it may be necessary to forcibly close the eyes with each blink in order to be sure the lids close completely.

At times a patient may unknowingly rub and scratch the eye after an injection because of persistent numbing after an injection.  Therefore, it is very important to avoid touching the eye for 15-30 minutes after an injection.  If the eye needs to be dried off, a clean tissue may be used with a gently damping or blotting motion in the corner of the eye where the lids come together at the bridge of the nose.  It is best not to move the tissue left and right or up and down in a rubbing fashion.  Once the eye becomes dry or irritated for any reason listed above, it may take 1-2 days for the pain to go away and the eye to return to normal. 

Rarely, a drug that is injected into the eye can cause an inflammation that causes pain or blurred vision.  The doctor makes this diagnosis by examining the eye under the biomicroscope (called a slit lamp).  If a medication is determined to be the cause of inflammation, it is treated with prescription eye drops and the offending drug is not used again in that patient in the future. 

Infection is an extremely rare cause of pain after an eye injection.  In about one in several thousand injections, germs may enter the eye through the needle tract after an eye injection.  This rare infection is called endophthalmitis (pronounced like “end-off-thal-my-tiss”).  Symptoms usually start with pain, redness, and loss of vision several days to a few weeks after an injection.  There is no perfect way to prevent endophthalmitis.  The doctor uses techniques like applying betadine before the injection.  The patient tries to avoid contaminating the eye by avoiding exposure the unclean areas (like a barnyard) and avoid rubbing the eyes after injection.  Endophthalmitis is very serious and may result in permanent loss of vision.  Therefore, any patient having deep aching pain, increasing redness, and loss of vision starting several days or weeks after an eye injection should notify their eye doctor for prompt evaluation.  

What can be done to make the eye feel better?

If the cause of the pain and irritation is from betadine, drying, or rubbing the eye, the best treatment is lubrication.  Lubricants are available over-the-counter in the form of eye drops, eye gels, and eye ointments (see examples at the end of this article).  The thicker the lubricant, the better the relief of pain and discomfort.  However, gels and ointments may be difficult to place into the eye and they tend to make the vision blurry for several minutes or more.  Lubricants may be used as often as needed.  Resting the eyes closed may also provide relief.  Cold compresses help many patients.  Over-the-counter pain medications like ibuprofen and/or Tylenol may be helpful.  Prescription pain medications are rarely needed and may cause undesirable side effects.

If the cause of the pain and irritation is from a drug reaction or from infection inside the eye, the doctor will prescribe special anti-inflammatory eye drops.  If the eye exam shows infection, antibiotic injections must be given into the eye and surgery in the operating room may be necessary. 

If pain keeps occurring after eye injections despite taking the measures listed above, sometimes prescription eye medication can help. Non-steroid (NSAID) eyes drops or steroid/antibiotic ointments may help prevent the pain. Most instances of pain after eye injections may be avoidable. Please talk with your eye doctor to help resolve the problem in order to undergo treatment without pain.

Check the current price of Systane Gel on Amazon.

Gels are easier to apply than ointments and may be used immediately after an eye injection to prevent eye pain and they may be used later to soothe eye discomfort.

Check the current price of Lacri-Lube on Amazon.

Ointments are more difficult to place in the eye. However, they provide longer duration of action. They may be used immediately after an eye injection to prevent eye pain and they may be used later to soothe eye discomfort.

By Scott E. Pautler, MD

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