The risk of stroke with treatment of Age-Related Macular Degeneration

The mainstay of treatment of wet-type age-related macular degeneration (AMD) requires the intraocular injection of medication (e.g. Avastin, Lucentis, Eylea, Beovu, and Vabysmo) to prevent loss of vision. Although effective, this treatment entails some degree of risk. For example, infection may occur at a rate of about one in one thousand to one in five thousand injections. Moreover, there may be a low increased risk of stroke.

Although some studies do not show increase risk (Campbell), other large studies have demonstrated an increased risk of stroke. In one study the increased risk of stroke appeared to be 1 in 127 patients within one year after starting treatment for AMD (Schlenker). These studies were unable to prove that the medication itself was responsible for the increased risk of stroke. For example, it may be that people with new-onset wet AMD are at a higher risk of stroke than others. In 2019 a population-based study demonstrated no increased risk of stroke and heart attack related to AMD treatment (see reference). Additional research in ongoing.

Given this information what are the options? Certainly, a patient may decide not to treat macular degeneration and risk loss of vision in an effort to decrease the risk of stroke. Another option may be to minimize the frequency of injections. That is, if the macular degeneration remains stable after several monthly injections, consider extending the time interval between injections. In this manner there is less exposure to the drug. Furthermore, if the wet-AMD appears to have reached end-stage with significant loss of vision, the injections might be stopped altogether. If done carefully, one may reduce the risk of a sudden recurrence of wet-AMD with further loss of vision while off treatment.

The type of medication used for injection has not been proven to make a difference in the risk of stroke. Although Martin et al found a slight increase in stroke risk with Avastin compared with Lucentis, these findings were not supported by Chakravarthy and Schlenker. More research is needed to better define risk of stroke and how we may minimize the risk. A recent meta-analysis of current data as of 2022 (Reibaldi) supports Lucentis over the other agents as being safer from a systemic risk of heart attack and stroke.  Please refer to my blog on medication choices for treating retinal problems.

By Scott E. Pautler, MD

For a telemedicine consultation with Dr Pautler, please send email request to spautler@rvaf.com. We accept Medicare and most insurances in Florida. Please include contact information (including phone number) in the email. We are unable to provide consultation for those living outside the state of Florida with the exception of limited one-time consultations with residents of the following states: Alabama, Arkansas, Connecticut, Georgia, Minnesota, and Washington.

References:

Ophthalmology 2012 119:1604-1608 Campbell

AJO 2015 160:569-580 Schlenker

Ophthalmology 2012 119:1388-1398 Martin

Ophthalmology 2012 119:1399-1411 Chakravarthy

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Retinal Artery Occlusion

globe anatomy
anatomy of the eye (click on image to enlarge)

What is a retinal artery occlusion?

The retina in your eye is like the film inside a camera. The retina “takes the picture” of objects you look at and sends the message to the brain. The retina is a living tissue, which requires blood supplied by tiny vessels called arteries. If a retinal artery becomes blocked, it is called a retinal artery occlusion.

What causes a retinal artery occlusion?

Usually a blockage occurs from a piece of hardened artery in the neck (carotid artery) which breaks away and flows “down stream” to lodge in a small retinal artery. Hardening of the arteries is due to aging, obesity, high cholesterol, high blood pressure, diabetes, and tobacco use. Therefor, patients with retinal artery occlusion are at risk of other complications of hardening of the arteries (e.g. heart attack and stroke).

Abnormal tissue from a heart valve may also be the source of blockage. Rarely, an occlusion may result from blood disorders or inflammation such as giant cell arteritis. Fibromuscular dysplasia is suspected in young patients with retinal artery occlusion.  Trauma may cause retinal artery occlusion by dissection of the carotid artery, often associated with neck pain.

What are the symptoms of a retinal artery occlusion?

A sudden, painless loss of vision is common. There may be loss of only the central vision, the side vision, or there may be a dark bar or band above or below the center of vision. The loss of vision may be temporary or permanent.

What treatment is available?

If the blockage is mild, some or all of the vision may return with time. Sometimes it is necessary to help relieve the blockage with eye drops, pills, or an office procedure to lower the pressure in the eye. The blockage may be overcome and the blood flow may resume if the pressure in the eye is decreased quickly. This treatment may bring back some or all of the vision, but sometimes no treatment can bring back any vision. If an underlying medical problem is found, it must be treated.

Your doctor is going to order appropriate tests and recommend the best course of action to take at this time. The retinal artery occlusion will not be worsened by your daily activities or by using your eyes. If you have any questions, please feel free to ask.

What general health issues are there?

Retina artery occlusion usually indicates the need for an urgent general medical evaluation for increased risk of stroke. About 10% to 15% of people who experience retinal artery occlusion will suffer from a stroke within three months. Half of those individuals will have a stroke within 48 hours of having eye symptoms. Those people who survive this initial high-risk period must still be monitored because there is a 40% risk of stroke or heart attack within ten years from the time of retinal artery occlusion. This important health issues are why it is important to undergo regular general medical evaluations and work to minimize factors that worsen hardening of the arteries. Such factors include physical inactivity, overweight, tobacco use, high blood pressure, high cholesterol, and diabetes.

Where do I go for urgent care?

An urgent MRI brain scan (diffusion-weighted imaging) may be performed at a stroke center such as those available through the emergency room at Adventist Hospital, St. Joseph’s Hospital, or Tampa General Hospital. The brain scan can identify strokes that may be present without symptoms. Such strokes need to be treated in the hospital to prevent complications of paralysis and death.

Other important studies may also be performed to identify underlying treatable conditions. Blood tests may identify giant cell arteritis, a treatable inflammation of the arteries. A carotid sonogram studies the circulation of major arteries in the neck that lead to the brain and eyes. An ECHO cardiogram may identify an abnormal heart valve or a blood clot in the heart. These findings may be treatable to reduce the risk of future stroke.

By Scott E. Pautler, MD

For a telemedicine consultation with Dr Pautler, please send email request to spautler@rvaf.com. We accept Medicare and most insurances in Florida. Please include contact information (including phone number) in the email. We are unable to provide consultation for those living outside the state of Florida with the exception of limited one-time consultations with residents of the following states: Alabama, Arkansas, Connecticut, Georgia, Minnesota, and Washington.

Tampa Stroke Centers:

Adventist Hospital Emergency Department

3100 East Fletcher Avenue

Tampa, FL 33613

(813) 971-6000

St. Joseph’s Hospital Emergency Department

3001 W Dr Martin Luther King Jr Blvd

Tampa, FL 33607

(813) 870-4000

Tampa General Hospital Emergency Department

1 Tampa General Circle

Tampa, FL 33606

(813) 844-7000

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